The name Jesse is primarily a gender-neutral name of Hebrew origin that means God's Gift.In the Bible, Jesse was the grandson of Ruth and Boaz.Jesse Jackson, activist and politician. Jesse James, famous outlaw. Jesse Ventura, professional wrestler and politician. Jesse McCartney, musician. Jesse Williams, actor. Jesse Owens, American track and field athlete and four-time Olympic gold medalist. Jesse Tyler Ferguson, actor. Jesse L. Martin, actor.